Method
The CBG human trial (Cuttler 2024)
The only human CBG dataset Atlas grades for anxiety and stress is Cuttler et al., published in Scientific Reports in 2024. It was an acute, double-blind, placebo-controlled crossover in 34 healthy adults given a single 20 mg oral dose, with self-reported anxiety, stress and mood as the endpoints. Atlas grades it Low because it was acute, self-reported and run in healthy volunteers. It does not support a treatment claim, and Peregrine had no part in it.
| Cuttler 2024 | What it is not | |
|---|---|---|
| n | 34 healthy adults | A patient trial |
| Dose | 20 mg oral, once | A labeled chronic dose |
| Design | DB, placebo, crossover | Parallel RCT vs a drug |
| Endpoints | Self-reported anxiety, stress, mood | PSG, biomarker, disease score |
| Atlas grade | Low | Established efficacy |
| Sponsor | Not Peregrine | A Peregrine study |
Origin
The paper is Cuttler et al., Scientific Reports, 2024. Atlas grades it Low: acute dosing, healthy volunteers, self-report, and mixed preclinical anxiety data behind it. Peregrine did not run or fund it.
Established
- The trial exists and is published.
- Design: double-blind, placebo-controlled, crossover, single dose.
- Population: healthy adults, not a diagnosed anxiety cohort.
Not yet
- Replication at other doses or durations.
- A primary clinical endpoint in a patient population.
- Any basis for writing ‘clinically proven’ on a CBG isolate.
Questions
Did CBG beat placebo for anxiety?
The paper reports lower self-reported anxiety and stress after 20 mg versus placebo in that crossover. Atlas still grades it Low because it is a single acute self-report study in healthy adults, and we use the same grade.
Is this Sleepz or Meliora data?
No. Sleepz is a finished formula in development and Meliora is skincare in development; neither has data here. This trial was a single dose of CBG in healthy adults.
Evidence language follows CBG Atlas (Peregrine-funded; editorial independence). Not medical advice. Not a disease claim.
Related
Educational, not medical advice. Nothing here diagnoses, treats, cures or prevents any disease. Wholesale isolates are ingredients, not finished supplements. Education is aligned with CBG Atlas, which Peregrine funds without editorial control.