CBDV
CBDV API status, reference standards, and a trial that missed
CBDV is the propyl analogue of CBD. It is the one compound in this group that has been through a real clinical programme — GW Pharmaceuticals' GWP42006 — which missed its primary endpoint in a Phase 2a epilepsy trial, and whose autism trials were terminated. That programme did not produce an approved drug, so there is no CBDV API. No pharmacopoeial standard exists either. Peregrine supplies research-grade CBDV isolate at ≥99.9% for method development and reference libraries.
- Cannabidivarin
- CAS 24274-48-4 · C19H26O2 · 286.42 g/mol
- API status
- No approved drug. The GWP42006 programme missed its Phase 2a endpoint.
- Standard status
- No USP or Ph. Eur. monograph. Manufacturer-certified CRMs only.
- What Peregrine sells today
- Research-grade isolate, ≥99.9%, 5 g upward, COA per lot.
Can I buy CBDV as an API today?
No. CBDV has the most clinical history of the compounds on this page and still has no approved drug behind it, which is the thing that would make the word API apply. GW Pharmaceuticals took CBDV into a Phase 2a epilepsy trial as GWP42006; it missed its primary endpoint. The autism trials were terminated.
That history is worth knowing precisely because it is the closest any of these compounds has come. An API needs an approved or investigational drug, GMP manufacture under ICH Q7, a qualified impurity profile under ICH Q3A and stability under ICH Q1A. A trial that did not read out does not create any of that.
Where do I buy a CBDV standard?
A reference-material producer, in milligrams. Two accreditations get confused here: ISO 17034 is the one for producing the material, ISO/IEC 17025 the one for testing against it.
Supelco's phyproof line carries CBDV, as do Cayman, Cerilliant and LGC.
Worth flagging for anyone building a method: CBDV and THCV share a molecular formula and molecular weight. Mass alone does not distinguish them. Retention time against a qualified standard, or structural identity by NMR, does.
What does GMP CBDV actually mean?
The same four-regime question as every other compound here. ICH Q7 is API GMP; 21 CFR 210/211 is drug-product GMP; 21 CFR 111 is dietary supplement GMP; ISO 22716 is cosmetics GMP. A claim without a named regime and a named auditor is not yet information.
What does pharma grade CBDV mean?
Not a defined term, and with no monograph for CBDV there is nothing behind it. Ask for the specification and the identity method instead — particularly here, given the isomer problem.
What ships from Peregrine today?
Research-grade CBDV isolate at ≥99.9% as a white to pale crystalline solid, for method development, reference libraries and minor-cannabinoid work. Lead times track varin biomass campaigns. A COA for the lot and an SDS on request ship with the material.
Peregrine is working to supply all of it — API-grade material, certified standards and GMP-declared volume — at research and industrial scale worldwide, through its own patented synthesis process.
Buying CBDV
Where do I buy CBDV API?
Not on the open market — though CBDV is the one compound in this group where API-grade material demonstrably existed. GW Pharmaceuticals ran GWP42006 through Phase 2 using CBDV made to drug standard. That material was made for a sponsor under a filing and never sold as a catalogue item, which is the usual shape of an API that exists but cannot be bought.
Peregrine's route to that grade is its own, and it is being built for volume rather than for a single trial — which is the difference between material a sponsor can buy and material a sponsor has to commission.
Can anyone supply bulk CBDV API?
No supplier can hand you bulk CBDV against an API specification today. Peregrine supplies research-grade CBDV isolate from 5 g upward with identity and assay on the lot certificate, which is the right material for method development, receptor work and formulation trials.
One thing to get right at the quote stage: CBDV and THCV are both propyl cannabinoids and they can co-elute on a method that was not built to separate them. If your incoming test cannot resolve the pair, purity by area percent will flatter whichever one you think you have.
Is there a sample CBDV API quantity?
A 5 g research cut serves as one. It ships to a named facility with the lot certificate, drawn from the same lot as any larger order from that lot.
If you are qualifying against the published CBDV literature, note that the completed randomised trial did not meet its primary endpoint. Peregrine reports that plainly rather than around it, because a buyer who discovers it later has a reason to doubt everything else on the certificate.
Who manufactures CBDV API?
CBDV is the one compound here with a real pharmaceutical manufacturing history, and it is not merchant supply. Material made to support the clinical programme was made for that programme — captive supply, inside a sponsor's own chain, never offered on the open market. So a buyer today is not choosing between that and a catalogue; the catalogue is the market.
What that leaves is the ordinary qualification: who runs the route, what the impurity profile looks like beside CBD and the other propyl analogues, and whether the analytical method can actually separate them. That last one is where CBDV suppliers separate, because a method that co-elutes CBDV and CBD makes every assay figure on the certificate meaningless.
Questions
I can find CBDV API in supplier catalogues — is it the same as GW's material?
No. The CBDV made for GWP42006 was manufactured to drug standard for a clinical filing and never sold as a catalogue item. Material listed today is high-purity research-grade isolate, which is a different product with a different file behind it, whatever the listing calls it.
Is CBDV an active pharmaceutical ingredient?
Not today. GW Pharmaceuticals' CBDV programme did not produce an approved drug, so no CBDV API exists. Peregrine sells it as a research-grade ingredient and is working toward API-grade supply.
Is there a USP standard for CBDV?
No. There is no USP Reference Standard or European Pharmacopoeia Chemical Reference Substance for CBDV. Commercial reference-material producers certify their own.
Can Peregrine supply a CBDV sample?
Yes, the 5 g research cut, shipped to a named facility with the lot COA.
How do I tell CBDV from THCV?
Not by mass. They share the formula C19H26O2 and a molecular weight of 286.42. Retention time against a qualified reference standard, or structural confirmation by NMR, separates them.
What happened to the CBDV epilepsy trial?
GW Pharmaceuticals' GWP42006 missed its primary endpoint in a Phase 2a trial, and the autism trials were terminated. Peregrine states this because a buyer evaluating the compound should know it.
Which CBDV API supplier should I qualify?
No. The only CBDV made to pharmaceutical standards was captive supply for a clinical programme and was never sold on the open market. What is available is research-grade isolate, Peregrine's at ≥99.9%. The test question for any CBDV supplier is whether the analytical method separates CBDV from CBD — if the two co-elute, the assay figure on the certificate means nothing.
Sources
- 21 CFR 210.3(b)(7)FDA's definition of an active ingredient
- ICH Q7Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients, Step 4, 2000
- ICH Q3A(R2)Impurities in New Drug Substances, Step 4, 2006
- ISO 17034General requirements for the competence of reference material producers (paywalled)
Related: What CBDV isHow to read a COAQuestions to ask a supplierQuality methods
The vocabulary
- What is an API (active pharmaceutical ingredient)?The regulatory definition, the five things it actually requires, and why a purity figure is not one of them.
- API grade vs research grade: what actually changesThe molecule is the same. What differs is how much of its history is documented, and who answers for it.
- Where do I buy a cannabinoid reference standard?Who actually sells them, what the certificate must say, and why ISO 17034 and 17025 are not interchangeable.
- GMP ingredients: which GMP, and what each one coversFour unrelated regimes share the word. Which certificate means what, and the three questions that settle a claim.
- What does pharma grade mean?An empty phrase doing a real job badly — and the five-line specification that replaces it.
- How do you qualify a cannabinoid API supplier?Directory listings promise DMF and CEP against compounds that can hold neither. The questions that separate a manufacturer from a broker.
Other compounds
- CBGNo approved drug uses CBG, no USP standard exists, and what GMP CBG usually means.
- CBGAThe precursor acid: no monograph, no drug programme, and what its stability question is.
- CBGVThe varin branch precursor: scarce, campaign-based, no monograph.
- THCVWhere today's purity falls short of an API bar, stated plainly.
- CBNThe only one with any pharmacopoeial presence — and why an impurity limit is not a standard.
- Cannflavin AA prenylated flavone, not a cannabinoid: preclinical, milligram-scale, no bulk supply anywhere.